Vaughan trained in Oxford, Bristol and Australia. He was a consultant paediatrician in Exeter from 2002 to 2015 during which time he held clinical management roles including Medical Director. He chaired the South West Clinical Senate from its inception and established the first Citizens Senate Council. Between 2015 and 2019 he was the NHS South Regional Medical Director for Specialised Commissioning and since 2019 has been the Regional Medical Director for NHS England & NHS Improvement in the South East.
As SE Regional Medical Director and CCIO his roles include clinical leadership and improvement support to NHS organisations and Integrated Care Systems, Vaughan is the SRO for a wide range of clinical programmes supporting COVID recovery and Long-Term Plan delivery including system level transformation. He is a strong advocate of clinical networks and provider collaboration.