Mark grew up in the West Country. He joined the Civil Service as a fast stream trainee in 1983. From June 2017 until June 2022 he was a Director General in the Cabinet Office and Secretary to the Grenfell Tower Public Inquiry. Since 1st July 2022, he has been Chief Executive of NHS Greater Manchester Integrated Care.

Mark has worked in the Benefits Agency, as HR Director of the (then) Department for Social Security, and as deputy Chief Executive of Jobcentre Plus. He has been Chief Executive of the Sector Skills Development Agency, promoting employer investment in skills, and Labour Market Director in the DWP during the 2009 recession. Immediately prior to his appointment to the Grenfell Tower Inquiry he was Director of the Office for Civil Society at the Cabinet Office (and later DCMS) with responsibility for social action, social investment, support for charities, business partnerships and youth policy.

Mark has been a Director of Working Links (Employment) Ltd, an advisor for the Prince’s Trust Team (formerly volunteers) programme, and a Public Member of Network Rail. He is Chair of the Estates and Finance Committee at Huddersfield University, and a Trustee of the Clore Social Leadership Foundation. He is also Chair of the Civil Service Sports Council (CSSC). In January 2010, Mr Fisher received a CBE.

Mark lives in Holmfirth, West Yorkshire.